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For the 2025-26 school year, there are 15 public schools serving 4,306 students in Greenville, MS (there are , serving 1,247 private students). 78% of all K-12 students in Greenville, MS are educated in public schools (compared to the MS state average of 89%).

The top ranked public schools in Greenville, MS are O'bannon Elementary School, Boyd Elementary School and Trigg Elementary School. Overall testing rank is based on a school's combined math and reading proficiency test score ranking.

Greenville, MS public schools have an average math proficiency score of 31% (versus the Mississippi public school average of 53%), and reading proficiency score of 23% (versus the 42% statewide average). Schools in Greenville have an average ranking of 2/10, which is in the bottom 50% of Mississippi public schools.

Minority enrollment is 98% of the student body (majority Black), which is more than the Mississippi public school average of 58% (majority Black).