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For the 2025-26 school year, there are 2 public schools serving 826 students in Jefferson, SC (there are , serving 12 private students). 99% of all K-12 students in Jefferson, SC are educated in public schools (compared to the SC state average of 92%).

The top ranked public schools in Jefferson, SC are Jefferson Elementary School and New Heights Middle School. Overall testing rank is based on a school's combined math and reading proficiency test score ranking.

Jefferson, SC public schools have an average math proficiency score of 15% (versus the South Carolina public school average of 43%), and reading proficiency score of 30% (versus the 52% statewide average). Schools in Jefferson have an average ranking of 1/10, which is in the bottom 50% of South Carolina public schools.

Minority enrollment is 59% of the student body (majority Black), which is more than the South Carolina public school average of 53% (majority Black).